Invention Grant
US07829707B2 Pyrrolo [3,2-d]pyrimidin-4-one derivatives and their use in therapy
有权
吡咯并[3,2-d]嘧啶-4-酮衍生物及其在治疗中的用途
![Pyrrolo [3,2-d]pyrimidin-4-one derivatives and their use in therapy](/docs/US/2010-11-09/US07829707B2/abs.jpg.600x600.jpg)
- Patent Title: Pyrrolo [3,2-d]pyrimidin-4-one derivatives and their use in therapy
- Patent Title (中): 吡咯并[3,2-d]嘧啶-4-酮衍生物及其在治疗中的用途
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Application No.: US11720913Application Date: 2005-12-05
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Publication No.: US07829707B2Publication Date: 2010-11-09
- Inventor: Anders Bogevig , Yvonne Lo-Alfredsson , Donald Pivonka , Anna-Karin Tiden
- Applicant: Anders Bogevig , Yvonne Lo-Alfredsson , Donald Pivonka , Anna-Karin Tiden
- Applicant Address: SE Sodertalje
- Assignee: AstraZeneca AB
- Current Assignee: AstraZeneca AB
- Current Assignee Address: SE Sodertalje
- Priority: SE0402972 20041206; SE0501093 20050513
- International Application: PCT/SE2005/001835 WO 20051205
- International Announcement: WO2006/062465 WO 20060615
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61P9/10 ; A61P29/00
![Pyrrolo [3,2-d]pyrimidin-4-one derivatives and their use in therapy](/abs-image/US/2010/11/09/US07829707B2/abs.jpg.150x150.jpg)
Abstract:
There are disclosed novel compounds of formula (I) wherein R1, R12, L, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardiovascular disorders and respiratory disorders.
Public/Granted literature
- US20080221136A1 Novel Pyrrolo [3,2-D]Pyrimidin-4-One Derivatives And Their Use In Therapy Public/Granted day:2008-09-11
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