Invention Grant
- Patent Title: Method for producing solifenacin or salts thereof
- Patent Title (中): 索非那新或其盐的制备方法
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Application No.: US11587826Application Date: 2005-04-25
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Publication No.: US07829715B2Publication Date: 2010-11-09
- Inventor: Masatoshi Inakoshi , Yusuke Ishii
- Applicant: Masatoshi Inakoshi , Yusuke Ishii
- Applicant Address: JP Tokyo
- Assignee: Astellas Pharma Inc.
- Current Assignee: Astellas Pharma Inc.
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Priority: JPP.2004-133283 20040428
- International Application: PCT/JP2005/007771 WO 20050425
- International Announcement: WO2005/105795 WO 20051110
- Main IPC: C07D453/02
- IPC: C07D453/02

Abstract:
There is provided a novel method for producing solifenacin or a salt thereof which is useful as a medicine, particularly a therapeutic agent and/or a preventive agent for a urinary organ system disease such as pollakiuria or urinary incontinence. Illustratively, there are provided (1) a method for producing solifenacin in which 2-(1H-Imidazolylcarbony1)-1-phenyltetrahydroisoquinoline is used as the starting material, (2) a method for producing solifenacin succinate in which (1RS)-phenyltetrahydroisoquinoline-carboxylic acid quinuclidinyl ester is used as the starting material, (3) a method for producing solifenacin in which a lower alkyl quinuclidinyl carbonate is used as the starting material and (4) a method for producing solifenacin in which phenyltetrahydroisoquinoline-carboxylic acid secondary lower alkyl or tertiary lower alkyl ester is used as the starting material and allowed to react with an alkali metal lower alkoxide.
Public/Granted literature
- US20070185329A1 Method for producing solifenacin or salts thereof Public/Granted day:2007-08-09
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