Invention Grant
- Patent Title: (Arylamidoaryl)squaramide compounds
- Patent Title (中): （芳酰氨基芳基）方酰胺化合物
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Application No.: US11227699Application Date: 2005-09-15
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Publication No.: US07829717B2Publication Date: 2010-11-09
- Inventor: Arlindo L. Castelhano , Andrew Crew , Hanqing Dong , An-Hu Li , Li Qiu , Alun Smith , Lawrence Tardibono , Tao Zhang
- Applicant: Arlindo L. Castelhano , Andrew Crew , Hanqing Dong , An-Hu Li , Li Qiu , Alun Smith , Lawrence Tardibono , Tao Zhang
- Applicant Address: US NY Ardsley
- Assignee: OSI Pharmaceuticals, Inc.
- Current Assignee: OSI Pharmaceuticals, Inc.
- Current Assignee Address: US NY Ardsley
- Main IPC: C07D215/12
- IPC: C07D215/12 ; A61K31/47
Abstract:
Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R5, m and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.
Public/Granted literature
- US20060111349A1 (Arylamidoaryl)squaramide compounds Public/Granted day:2006-05-25
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