Invention Grant
US07829737B2 Protein tyrosine phosphatase inhibitors and methods of use thereof
有权
蛋白酪氨酸磷酸酶抑制剂及其使用方法
- Patent Title: Protein tyrosine phosphatase inhibitors and methods of use thereof
- Patent Title (中): 蛋白酪氨酸磷酸酶抑制剂及其使用方法
-
Application No.: US12043872Application Date: 2008-03-06
-
Publication No.: US07829737B2Publication Date: 2010-11-09
- Inventor: Mark Arnold Thomas Blaskovich , Ted Baughman , Thomas Little , Maher Qabar , Lauri Marie Schultz , Feng Hong , William Patt , Gangadhar Nagula , Jennifer Lynn Gage , James Jeffry Howbert
- Applicant: Mark Arnold Thomas Blaskovich , Ted Baughman , Thomas Little , Maher Qabar , Lauri Marie Schultz , Feng Hong , William Patt , Gangadhar Nagula , Jennifer Lynn Gage , James Jeffry Howbert
- Applicant Address: US WA Bothell
- Assignee: Ceptyr, Inc.
- Current Assignee: Ceptyr, Inc.
- Current Assignee Address: US WA Bothell
- Agency: Merchant & Gould
- Main IPC: C07F9/02
- IPC: C07F9/02
Abstract:
The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.
Public/Granted literature
- US20080161592A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF Public/Granted day:2008-07-03
Information query
