A musical instrument slide including a body portion and a light source. The light source includes a switch for selective activation, enabling the slide body to emit light when activated. As the musician moves the slide across the strings as the instrument, such as a guitar, is played, a visual effect is created by the movement of the light. The body portion preferably is constructed of a material to pass light therethrough, and can be either wholly or partially clear or translucent, or a combination of both. Alternatively or in addition to the light source, the slide body can include an eccentric motor that causes the slide body to vibrate. This vibration, in turn, causes vibration of the guitar strings, or other string instrument, as the slide is positioned on the strings, or moved along the strings, by the musician.