Visualization systems for rendering images from a multi-dimensional data set, include an interactive visualization system configured to accept user input to define at least one explicit prioritized feature in an image rendered from a multi-dimensional image data set. The at least one prioritized feature is automatically electronically rendered with high or full quality in different interactively requested rendered images of the image data while other non-prioritized features are rendered at lower quality. The visualization system may optionally include a rendering system configured to render images by electronically assigning a level of detail for different tiles associated with an image, each level of detail having a number of pixel samples to be calculated to thereby accelerate image processing.