Scheduling threads in a multi-processor computer system including establishing an interrupt threshold for a thread, where the interrupt threshold represents a maximum permissible number of interrupts during thread execution on a processor; executing the thread on a current processor, where the thread has thread affinity for one or more processors including the current processor; counting a number of interrupts during execution of the thread on the current processor; and removing thread affinity for the current processor in dependence upon the counted number of interrupts and the interrupt threshold.