Invention Grant
US07834171B2 Modified polynucleotides for reducing off-target effects in RNA interference
有权
用于减少RNA干扰中的脱靶效应的修饰多核苷酸
- Patent Title: Modified polynucleotides for reducing off-target effects in RNA interference
- Patent Title (中): 用于减少RNA干扰中的脱靶效应的修饰多核苷酸
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Application No.: US11857732Application Date: 2007-09-19
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Publication No.: US07834171B2Publication Date: 2010-11-16
- Inventor: Devin Leake , Angela R Reynolds , Anastasia Khvorova , William Marshall
- Applicant: Devin Leake , Angela R Reynolds , Anastasia Khvorova , William Marshall
- Applicant Address: US CO Lafayette
- Assignee: Dharmacon, Inc.
- Current Assignee: Dharmacon, Inc.
- Current Assignee Address: US CO Lafayette
- Agency: Kalow & Springut, LLP
- Agent Scott D. Locke, Esq.
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61K48/00
Abstract:
Methods and compositions for performing RNA interference with decreased off-target effects are provided. The methods and compositions permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of modifications to the siRNA. Uniquely modified siRNAs have been developed that reduce off-target effects incurred in gene-silencing. The modifications comprise 2′-O-alkyl or mismatch modification(s) at specific positions on the sense and/or antisense strands.
Public/Granted literature
- US20080242851A1 MODIFIED POLYNUCLEOTIDES FOR REDUCING OFF-TARGET EFFECTS IN RNA INTERFERENCE Public/Granted day:2008-10-02
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