Invention Grant
US07834174B2 Per-6-guanidino-, alkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of DNA and intercellular delivery
有权
每6-胍基 - ，烷基氨基 - 环糊精，它们的合成方法及其用于压制DNA和细胞间传递的用途
- Patent Title: Per-6-guanidino-, alkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of DNA and intercellular delivery
- Patent Title (中): 每6-胍基 - ，烷基氨基 - 环糊精，它们的合成方法及其用于压制DNA和细胞间传递的用途
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Application No.: US11662450Application Date: 2005-04-21
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Publication No.: US07834174B2Publication Date: 2010-11-16
- Inventor: Irene M. Mavridis , Konstantina Yannakopoulou , Kyriaki Eliadou , Nikolaos Mourtzis , Chrysi Aggelidou
- Applicant: Irene M. Mavridis , Konstantina Yannakopoulou , Kyriaki Eliadou , Nikolaos Mourtzis , Chrysi Aggelidou
- Agency: Porzio, Bromberg & Newman, P.C.
- Priority: GR20040100361 20040910
- International Application: PCT/GR2005/000013 WO 20050421
- International Announcement: WO2006/027631 WO 20060316
- Main IPC: A61K31/713
- IPC: A61K31/713 ; A61K31/724 ; C12N15/63
Abstract:
The invention relates to new compounds of type hexakis(6-deoxy-6-NH(CH2)n—R1)α-cyclodextrin and heptakis(6-deoxy-6-NH(CH2)n—R1)-(β-cyclodextrin, and octakis(6-deoxy-6-NH(CH2)n—R1)-γ-cyclodextrin, where n=2-6 when R1=NH2 and n=0 when R1=C(═NH)NH2 and n=2-6 when R1=NH—C(═NH)NH2 and their use in the compaction of DNA and in cell permeation. The invention also relates to methods of synthesis of the above compounds.
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