Invention Grant
US07838644B2 Epimerized derivatives of K5 polysaccharide with a very high degree of sulfation
有权
具有很高硫酸化程度的K5多糖的差向异构衍生物
- Patent Title: Epimerized derivatives of K5 polysaccharide with a very high degree of sulfation
- Patent Title (中): 具有很高硫酸化程度的K5多糖的差向异构衍生物
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Application No.: US10518302Application Date: 2003-06-17
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Publication No.: US07838644B2Publication Date: 2010-11-23
- Inventor: Pasqua Anna Oreste , Giorgio Zoppetti
- Applicant: Pasqua Anna Oreste , Giorgio Zoppetti
- Applicant Address: IT Milan
- Assignee: Glycores 2000 S.R.L.
- Current Assignee: Glycores 2000 S.R.L.
- Current Assignee Address: IT Milan
- Agency: Nixon & Vanderhye P.C.
- Priority: ITMI2002A1345 20020618; ITMI2002A1346 20020618; ITMI2002A1854 20020827
- International Application: PCT/IB03/02338 WO 20030617
- International Announcement: WO03/106504 WO 20031224
- Main IPC: C08B37/10
- IPC: C08B37/10 ; C08B37/00 ; C07H5/04 ; C07H5/06 ; A61K31/727
Abstract:
A new method is described for the oversulfation of epiK-N sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.
Public/Granted literature
- US20060014718A1 Epimerized derivatives of k5 polysaccharide with a very high degree of sulfation Public/Granted day:2006-01-19
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