Invention Grant
- Patent Title: Function of autophagy genes in cell death
- Patent Title (中): 自噬基因在细胞死亡中的功能
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Application No.: US11119569Application Date: 2005-05-02
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Publication No.: US07838645B2Publication Date: 2010-11-23
- Inventor: Eric H. Baehrecke , Ajjai Alva , Michael J. Lenardo , Yu Li
- Applicant: Eric H. Baehrecke , Ajjai Alva , Michael J. Lenardo , Yu Li
- Applicant Address: US MD College Park US MD Bethesda
- Assignee: University of Maryland College Park,National Institutes of Health
- Current Assignee: University of Maryland College Park,National Institutes of Health
- Current Assignee Address: US MD College Park US MD Bethesda
- Agency: Intellectual Property/Technology Law
- Agent Kelly K. Reynolds; Steven J. Hultquist
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07K16/00
Abstract:
The present invention relates to a new molecular pathway in which activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy. Further, autophagic death is induced by caspase 8 inhibition and expression of the mammalian genes ATG7 and beclin.
Public/Granted literature
- US20050276809A1 Function of autophagy genes in cell death Public/Granted day:2005-12-15
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