Invention Grant
- Patent Title: Azaindole derivative having PGD2 receptor antagonistic activity
- Patent Title (中): 具有PGD2受体拮抗活性的阿维醇衍生物
-
Application No.: US11989132Application Date: 2006-07-20
-
Publication No.: US07842692B2Publication Date: 2010-11-30
- Inventor: Akira Kugimiya , Itsuo Makino , Naohiro Onodera
- Applicant: Akira Kugimiya , Itsuo Makino , Naohiro Onodera
- Applicant Address: JP Osaka
- Assignee: Shionogi & Co., Ltd.
- Current Assignee: Shionogi & Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2005-212910 20050722; JP2005-362754 20051216
- International Application: PCT/JP2006/314346 WO 20060720
- International Announcement: WO2007/010965 WO 20070125
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/5377 ; A61K31/437

Abstract:
The present invention creates an azaindole derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further providing a therapeutic agent for treating allergic diseases.A compound of the general formula (I) wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a 3- to 8-membered nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of —X1═X2—X3═X4— is a formula of —C(R1)═C(R2)—C(R3)═N— etc.; R1, R2, R3, R4 and R5 are independently a hydrogen atom or a halogen atom etc.; R6 is optionally substituted C1-C6 alkyloxy etc.; R7 is independently a halogen atom etc.; R8 is optionally substituted C1-C6 alkyl etc.; R9 is carboxy etc.; M is sulfonyl etc.; Y is a single bond etc.; L1, L2 and L3 are a single bond or alkylene optionally containing one or two heteroatoms etc.; n is 0 etc.; q is 0 etc.; a pharmaceutically acceptable salt or hydrate thereof.
Public/Granted literature
- US20090197881A1 Azaindole Derivative Having PGD2 Receptor Antagonistic Activity Public/Granted day:2009-08-06
Information query