A method for compensating a power amplifier based on operational-based changes begins by measuring one of a plurality of operational parameters of the power amplifier to produce a measured operational parameter. The method continues by comparing the measured operational parameter with a corresponding one of a plurality of desired operational parameter settings. The method continues by, when the comparing of the measured operational parameter with the corresponding one of a plurality of desired operational parameter settings is unfavorable, determining a difference between the measured operational parameter and the corresponding one of a plurality of desired operational parameter settings. The method continues by calibrating the one of the plurality of operational settings based on the difference.