System and method for distributed execution of a graphical program. First and second icons associated with respective execution targets are displayed on a display. Each icon has an interior and specifies execution of a respective graphical program portion positioned in the interior of the icon on the respective execution target. First and second graphical program portions are respectively displayed in the interiors of the first and second icons, where each graphical program portion comprises a respective one or more interconnected nodes that visually indicate functionality of the graphical program portion. One or more wires connecting the first graphical program portion and the second graphical program portion are display. During execution of the graphical program, the first and second graphical program portions execute respectively on the first and second execution targets, and the first graphical program portion and the second graphical program portion communicate as specified by the one or more wires.