Invention Grant
US07846442B2 Methods of treating rheumatoid arthritis with an anti-TNF-alpha antibodies and methotrexate
无效
用抗TNF-α抗体和甲氨蝶呤治疗类风湿性关节炎的方法
- Patent Title: Methods of treating rheumatoid arthritis with an anti-TNF-alpha antibodies and methotrexate
- Patent Title (中): 用抗TNF-α抗体和甲氨蝶呤治疗类风湿性关节炎的方法
-
Application No.: US11225631Application Date: 2005-09-12
-
Publication No.: US07846442B2Publication Date: 2010-12-07
- Inventor: Marc Feldmann , Ravinder N. Maini
- Applicant: Marc Feldmann , Ravinder N. Maini
- Applicant Address: GB London
- Assignee: The Mathilda and Terence Kennedy Institute of Rheumatology Trust
- Current Assignee: The Mathilda and Terence Kennedy Institute of Rheumatology Trust
- Current Assignee Address: GB London
- Agency: Cooper & Dunham LLP
- Agent John P. White
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/24 ; A01N43/58
Abstract:
Methods for treating and/or preventing a TNF-mediated disease in an individual are disclosed. Also disclosed is a composition comprising methotrexate and an anti-tumor necrosis factor antibody. TNF-mediated diseases include rheumatoid arthritis, Crohn's disease, and acute and chronic immune diseases associated with transplantation.
Public/Granted literature
- US20060099212A1 TNFalpha antagonists and methotrexate in the treatment of TNF-mediated disease Public/Granted day:2006-05-11
Information query
