Invention Grant
US07846448B2 DNA sequence, and recombinant preparation of the grass pollen allergen Lol p4
有权
DNA序列，重组制备草花粉过敏原Lol p4
- Patent Title: DNA sequence, and recombinant preparation of the grass pollen allergen Lol p4
- Patent Title (中): DNA序列，重组制备草花粉过敏原Lol p4
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Application No.: US10583093Application Date: 2004-12-01
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Publication No.: US07846448B2Publication Date: 2010-12-07
- Inventor: Andreas Nandy , Helmut Fiebig , Oliver Cromwell
- Applicant: Andreas Nandy , Helmut Fiebig , Oliver Cromwell
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano & Branigan, P.C.
- Priority: DE10359352 20031216
- International Application: PCT/EP2004/013663 WO 20041201
- International Announcement: WO2005/058936 WO 20050630
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K39/00 ; A61K39/35 ; A61K39/36 ; A01N37/18 ; C07K1/00 ; C07K14/00 ; C07K17/00
Abstract:
The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilized for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies.
Public/Granted literature
- US20070154496A1 Dna sequence, and recombinant preparation of the grass pollen allergen lol p4 Public/Granted day:2007-07-05
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