Invention Grant
US07846722B2 Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity
有权
梭菌毒素活性的发光共振能量转移（LRET）测定
- Patent Title: Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity
- Patent Title (中): 梭菌毒素活性的发光共振能量转移（LRET）测定
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Application No.: US11754046Application Date: 2007-05-25
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Publication No.: US07846722B2Publication Date: 2010-12-07
- Inventor: Dudley J. Williams , Marcella A. Gilmore , Lance E. Steward , Marc Verhagen , Kei Roger Aoki , Ester Fernandez-Salas
- Applicant: Dudley J. Williams , Marcella A. Gilmore , Lance E. Steward , Marc Verhagen , Kei Roger Aoki , Ester Fernandez-Salas
- Applicant Address: US CA Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: US CA Irvine
- Agent Kenton Abel; Debra Condino
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; C12N5/071
Abstract:
Clostridial toxin substrates comprising a lanthanide donor complex, an acceptor, and a Clostridial toxin recognition sequence including a cleavage site; methods for determining the activity of a Clostridial toxin from a test sample using such Clostridial toxin substrates; cell compositions comprising such Clostridial toxin substrates and a Clostridial toxin receptor; and methods for determining the activity of a Clostridial toxin from a test sample using such cell compositions.
Public/Granted literature
- US20080220456A1 LUMINESCENCE RESONANCE ENERGY TRANSFER (LRET) ASSAYS FOR CLOSTRIDIAL TOXIN ACTIVITY Public/Granted day:2008-09-11
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