Invention Grant
US07846910B2 Pharmaceutical composition, composition for screening therapeutics preventing and treating beta amyloid accumulation in brain comprising GCP II (glutamate carboxypeptidase II) as an active ingredient and method for screening using the same
有权
药物组合物，用于筛选预防和治疗包含GCP II（谷氨酸羧肽酶II）作为活性成分的脑中β淀粉样蛋白积累的治疗剂的组合物和使用其的筛选方法
- Patent Title: Pharmaceutical composition, composition for screening therapeutics preventing and treating beta amyloid accumulation in brain comprising GCP II (glutamate carboxypeptidase II) as an active ingredient and method for screening using the same
- Patent Title (中): 药物组合物，用于筛选预防和治疗包含GCP II（谷氨酸羧肽酶II）作为活性成分的脑中β淀粉样蛋白积累的治疗剂的组合物和使用其的筛选方法
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Application No.: US12064426Application Date: 2006-08-23
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Publication No.: US07846910B2Publication Date: 2010-12-07
- Inventor: Sang-Mee Ahn , So Young Seo , San Sook Chae
- Applicant: Sang-Mee Ahn , So Young Seo , San Sook Chae
- Applicant Address: KR Seoul
- Assignee: Korea Center for Disease Control and Prevention
- Current Assignee: Korea Center for Disease Control and Prevention
- Current Assignee Address: KR Seoul
- Agency: Klarquist Sparkman, LLP
- Priority: KR10-2005-0077372 20050823
- International Application: PCT/KR2006/003312 WO 20060823
- International Announcement: WO2007/024097 WO 20070301
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/00
Abstract:
The present invention relates to a pharmaceutical composition for the prevention and treatment for β-amyloid (Aβ) accumulation in brain comprising GCP-II (Glutamate carboxypeptidase-II) as an active ingredient, a composition for screening method of the same. GCP-II of the present invention not only degrades Aβ monomer and oligomer but also degrades soluble Aβ and insoluble Aβ, particularly aggregated Aβ, so that it can prevent the accumulation of Aβ in brain or reduce the accumulation, making it an excellent candidate for the therapeutic agent for Alzheimer's disease and Down's syndrome.
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