Invention Grant
- Patent Title: Pyrrolotriazine compounds as kinase inhibitors
- Patent Title (中): 吡咯啉三嗪化合物作为激酶抑制剂
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Application No.: US11869910Application Date: 2008-09-24
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Publication No.: US07846931B2Publication Date: 2010-12-07
- Inventor: Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
- Applicant: Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Elliott Korsen
- Main IPC: A61K31/53
- IPC: A61K31/53 ; A61P35/00 ; C07D401/06 ; C07D401/14
Abstract:
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
Public/Granted literature
- US20090048244A1 PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS Public/Granted day:2009-02-19
Information query
