Invention Grant
- Patent Title: Classification and diagnosis of the molecular basis of cholestasis
- Patent Title (中): 胆汁淤积分子基础的分类与诊断
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Application No.: US12011628Application Date: 2008-01-28
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Publication No.: US07847088B2Publication Date: 2010-12-07
- Inventor: Jorge Bezerra
- Applicant: Jorge Bezerra
- Applicant Address: US OH Cincinnati
- Assignee: Children's Hospital Medical Center
- Current Assignee: Children's Hospital Medical Center
- Current Assignee Address: US OH Cincinnati
- Agency: Taft Stettinius & Hollister LLP
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/11 ; C12Q1/68
Abstract:
The methods and compositions of the invention find use in the clinical diagnosis of cholestasis related syndromes, particularly PFIC types 1, 2, and 3; BRIC types 1 and 2; Alagille syndrome, and alpha1-antitrypsin deficiency. The compositions of the invention include isolated nucleic acid molecules and oligonucleotide pairs suitable for use in amplifying regions of cholestasis related genes. Compositions of the invention include a cholestasis related gene resequencing microarray suitable for determining the nucleotide sequence of a region of a cholestasis related gene. Knowledge of the nucleotide sequence of one or more regions of a patient's cholestasis related gene allows diagnosis of the patient's syndrome.
Public/Granted literature
- US20080254994A1 Classification and diagnosis of the molecular basis of cholestasis Public/Granted day:2008-10-16
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