A compression subsystem for a computed tomography system compresses projection data to for efficient data transfer and storage. The compression includes applying an attenuation profile to an array of projection data samples. The attenuation profile is a function of sample coordinates and determines attenuation values applied to the samples. The attenuated samples are encoded and packed for data transfer. Alternatively, difference operators are applied to the attenuated samples and the differences are encoded. The average number of bits per compressed sample is monitored and the attenuation profiles can be modified to achieve a desired number of bits per compressed sample. The compressed samples are decompressed prior to image reconstruction processing. Decompression includes decoding the compressed samples and applying a gain profile to the decoded samples to restore the original dynamic range. This abstract does not limit the scope of the invention as described in the claims.