Invention Grant
- Patent Title: Macrolactams by engineered biosynthesis
- Patent Title (中): 通过工程化生物合成的新戊酰胺
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Application No.: US12011068Application Date: 2008-01-23
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Publication No.: US07855192B2Publication Date: 2010-12-21
- Inventor: Gary W. Ashley , Hugo Menzella , Janice Lau Wee , John R. Carney
- Applicant: Gary W. Ashley , Hugo Menzella , Janice Lau Wee , John R. Carney
- Applicant Address: US NJ Princeton
- Assignee: Kosan Biosciences, Inc.
- Current Assignee: Kosan Biosciences, Inc.
- Current Assignee Address: US NJ Princeton
- Agent Elliott Korsen
- Main IPC: C07D225/06
- IPC: C07D225/06 ; A61K31/395 ; A61P35/00
Abstract:
Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynthesis of the natural starter unit 3-amino-5-hydroxybenzoic acid has been deleted.
Public/Granted literature
- US20080188450A1 Macrolactams by engineered biosynthesis Public/Granted day:2008-08-07
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