Invention Grant
US07855207B2 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adpribose) polymerase inhibitors
有权
6-链烯基和6-苯基烷基取代的2-喹啉酮和2-喹喔啉酮作为聚（adpribose）聚合酶抑制剂
- Patent Title: 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adpribose) polymerase inhibitors
- Patent Title (中): 6-链烯基和6-苯基烷基取代的2-喹啉酮和2-喹喔啉酮作为聚（adpribose）聚合酶抑制剂
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Application No.: US10595891Application Date: 2004-11-18
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Publication No.: US07855207B2Publication Date: 2010-12-21
- Inventor: Dominique Jean-Pierre Mabire , Jér{hacek over (o)}me Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
- Applicant: Dominique Jean-Pierre Mabire , Jér{hacek over (o)}me Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica, NV
- Current Assignee: Janssen Pharmaceutica, NV
- Current Assignee Address: BE Beerse
- Priority: WOPCT/EP03/13028 20031120; EP03078860 20031205
- International Application: PCT/EP2004/013163 WO 20041118
- International Announcement: WO2005/054201 WO 20050616
- Main IPC: A61K31/498
- IPC: A61K31/498
Abstract:
The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.
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