Invention Grant
US07855298B2 Azabicyclo (3.1.0.) hexane derivatives useful as modulators of dopamine D3 receptors
有权
可用作多巴胺D3受体调节剂的氮杂双环(3.1.0。)己烷衍生物
- Patent Title: Azabicyclo (3.1.0.) hexane derivatives useful as modulators of dopamine D3 receptors
- Patent Title (中): 可用作多巴胺D3受体调节剂的氮杂双环(3.1.0。)己烷衍生物
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Application No.: US10598200Application Date: 2005-02-21
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Publication No.: US07855298B2Publication Date: 2010-12-21
- Inventor: Luca Arista , Giorgio Bonanomi , Anna Maria Capelli , Federica Damiani , Romano Di Fabio , Gabriella Gentile , Dieter Hamprecht , Fabrizio Micheli , Luca Tarsi , Giovanna Tedesco , Silvia Terreni
- Applicant: Luca Arista , Giorgio Bonanomi , Anna Maria Capelli , Federica Damiani , Romano Di Fabio , Gabriella Gentile , Dieter Hamprecht , Fabrizio Micheli , Luca Tarsi , Giovanna Tedesco , Silvia Terreni
- Applicant Address: GB Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Middlesex
- Agent James M. Kanagy; Edward R. Gimmi; Charles M. Kinzig
- Priority: GB0403990.5 20040223; GB0404083.8 20040224; GB0417120.3 20040730
- International Application: PCT/EP2005/001940 WO 20050221
- International Announcement: WO2005/080382 WO 20050901
- Main IPC: C07D215/38
- IPC: C07D215/38

Abstract:
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: 1. wherein G is selected from a group consisting of: phenyl, pyridyl, benzothiazolyl, indazolyl; p is an integer ranging from 0 to 5; R1 is independently selected from a group consisting of: halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl; or corresponds to a group R5; R2 is hydrogen or C1-4alkyl; R3 is C1-4alkyl; R4 is hydrogen, or a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromatic group, or a 8- to 11-membered bicyclic group, any of which groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl; R5 is a moiety selected from the group consisting of: isoxazolyl, —CH2—N -pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2 -pyrrolidinonyl, and such a group is optionally substituted by one or two substituents selected from: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl; and when R1 is chlorine and p is 1, such R1 is not present in the ortho position with respect to the linking bond to the rest of the molecule; and when R1 corresponds to R5, p is 1; or a salt thereof which are useful as modulators of dopamine D3 receptors, e.g. to treat drug dependency or as antipsychotic agents.
Public/Granted literature
- US20070142438A1 Azabicyclo (3.1.0.) hexane derivatives useful as modulators of dopamine d3 receptors Public/Granted day:2007-06-21
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