A holographic storage and reproduction system and method with a servo are provided, wherein a servo mechanism is provided, such that the holographic interferogram is continuously stored in the holographic recording medium. When a reproduced signal is to be obtained, it can be retrieved quickly and accurately through the servo mechanism. Also, the intensity distribution of the reference light reflected by the holographic recording medium can be monitored and controlled, such that the relative distance and oblique angle between the storage and reproduction system and the holographic recording medium are analyzed and adjusted.