A dispenser for dispensing metered amounts of powdered material, such as baby formula, from a dispenser unit, or cartridge, that can be quickly and easily interconnected with the dispenser. The dispenser can accommodate formula bottles of various sizes and includes a dispensing plunger that provides an oscillating action to prevent compaction of the formula and functions to ensure even dispensing of the formula into the formula bottle. Uniquely, actuation of the dispensing plunger creates a negative pressure internally of the dispensing chamber of the dispenser so as to assist the uniform withdrawal of formula from the cartridge.