A method of generating three-dimensional (3D) full volume ultra-sound images with the uses of contrast agents includes acquiring ultrasound image data for multiple subvolumes (140,142,144,146) synchronized to an ECG (100) over multiple cardiac cycles (124,126,128,130) via triggering (104,114,106,116,108,118,110,120). Acquiring includes at least one of two acquisition protocols. The first acquisition protocol uses an output acoustic power insufficient for causing destruction of the contrast agents during ultrasound image data acquisition (10). The second acquisition protocol uses an output acoustic power sufficient for causing destruction of the contrast agents during ultrasound image data acquisition (10). Triggering (26,28) of respective ones of the ultrasound image data acquisitions of the multiple subvolumes (140,142,144,146) is selected to enable destroyed contrast agents to be replaced by new contrast agents prior to a subsequent triggering of ultrasound image data acquisition of a subsequent subvolume. Furthermore, ultrasound image data (22) from the multiple subvolumes is combined to generate the 3D full volume 15 ultrasound image data (24).