Tissues are provided as multi-ply tissue products having greater tactile sensation and resiliency in hand. Improved tissues may have a thickened and reduced density middle layer. The tissues may serve as applicators for chemical agents to be released during use of the tissue. A tissue having an improved tactile impression to the consumer, with enhanced resilience and high external bulk is disclosed. In one embodiment, a multi-ply structure having at least three plies is desirable. A middle or intermediate ply is comprised an increased thickness and a greater bulk is employed. In general, the exterior plies of the tissue are smooth and desirable to the consumer.