In accordance with one embodiment of the present invention, a method of operating an electrochemical conversion cell is provided wherein the method comprises the steps of (i) initiating a membrane dehydration sequence when the membrane is characterized by an initial membrane hydration λWET and (ii) maintaining the membrane dehydration sequence until the membrane is characterized by a target membrane hydration λDRY. According to the method, the membrane dehydration sequence is characterized by a drying rate that varies in a manner that substantially corresponds to a fatigue life contour map of the membrane. Additional methods and corresponding systems are contemplated.