Invention Grant
- Patent Title: Methods for identifying agents for preventing or treating proliferative diseases, and for inhibiting extracellular matrix or α1 type IV collagen
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Application No.: US10571511Application Date: 2004-09-09
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Publication No.: US07862993B2Publication Date: 2011-01-04
- Inventor: Toshio Doi , Hideharu Abe
- Applicant: Toshio Doi , Hideharu Abe
- Applicant Address: JP Tokyo JP Tokyo
- Assignee: Hubit Genomix, Inc.,Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Hubit Genomix, Inc.,Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2003-319538 20030911
- International Application: PCT/JP2004/013124 WO 20040909
- International Announcement: WO2005/026344 WO 20050324
- Main IPC: G01N33/48
- IPC: G01N33/48 ; G01N33/50 ; G01N33/53 ; G01N33/68
Abstract:
A method of detecting proliferative diseases causing sclerosis, comprising measuring the expression of at least one substance selected from the group consisting of STAT3, phosphorylated STAT3, Smad1, phosphorylated Smad1, activin receptor-like kinase 1, activin receptor-like kinase 3 and bone morphogenetic proteins in a biological sample. A kit therefor. A prophylactic and/or therapeutic agent for proliferative diseases causing sclerosis, comprising as an active ingredient a substance having an inhibitory effect on the expression of at least one substance selected from the group consisting of STAT3, phosphorylated STAT3, Smad1 and phosphorylated Smad1. A method of identifying substances effective in preventing and/or treating proliferative diseases causing sclerosis, comprising judging whether or not a test substance inhibits the expression of at least one substance selected from the group consisting of STAT3, phosphorylated STAT3, Smad1 and phosphorylated Smad1. A kit therefor.
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