Invention Grant
US07862994B2 Methods for inhibiting HIV-1 envelope glycoprotein-medicated membrane fusion
有权
用于抑制HIV-1包膜糖蛋白介导的膜融合的方法
- Patent Title: Methods for inhibiting HIV-1 envelope glycoprotein-medicated membrane fusion
- Patent Title (中): 用于抑制HIV-1包膜糖蛋白介导的膜融合的方法
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Application No.: US09904356Application Date: 2001-07-12
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Publication No.: US07862994B2Publication Date: 2011-01-04
- Inventor: Graham P. Allaway , Virginia M. Litwin , Paul J. Maddon
- Applicant: Graham P. Allaway , Virginia M. Litwin , Paul J. Maddon
- Applicant Address: US NY Tarrytown
- Assignee: Progenics Pharmaceuticals Inc.
- Current Assignee: Progenics Pharmaceuticals Inc.
- Current Assignee Address: US NY Tarrytown
- Agency: Cooper & Dunham LLP
- Agent John P. White
- Main IPC: C12Q1/70
- IPC: C12Q1/70 ; G01N33/53 ; C12P21/08 ; A61K39/395
Abstract:
This invention provides agents determined to be capable of inhibiting the fusion of a macrophage-tropic primary isolate of HIV-1 to a CD4+cell and agents determined to be capable of inhibiting the fusion of a T cell-tropic isolate of HIV-1 to a CD4+cell. This invention also provides methods to identify such agents. This invention further provides methods of inhibiting fusion of a macrophage-tropic primary isolate of HIV-1 with a CD+ cell and methods of inhibiting fusion of a T cell-tropic isolate of HIV-1 with a CD4+cell susceptible to infection by a T cell-tropic isolate of HIV-1.
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