Invention Grant
- Patent Title: Fucose transporter
- Patent Title (中): 岩藻糖转运蛋白
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Application No.: US10561191Application Date: 2004-06-18
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Publication No.: US07863042B2Publication Date: 2011-01-04
- Inventor: Masayuki Tsuchiya , Shigeyuki Iijima , Izumi Sugo , Yasuo Sekimori , Kenju Ueno , Kiyoshi Habu
- Applicant: Masayuki Tsuchiya , Shigeyuki Iijima , Izumi Sugo , Yasuo Sekimori , Kenju Ueno , Kiyoshi Habu
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP.
- Priority: JP2003-174006 20030618; JP2003-174010 20030618; JP2003-282081 20030729; JP2003-282102 20030729
- International Application: PCT/JP2004/008956 WO 20040618
- International Announcement: WO2005/017155 WO 20050224
- Main IPC: C07H17/00
- IPC: C07H17/00

Abstract:
The present invention provides a gene encoding a fucose transporter, a fucose transporter polypeptide, a method for screening for a compound that binds to a fucose transporter or a compound that inhibits fucose transport activity, a cell having inhibited fucose transporter functions, and a cell wherein the expression of the fucose transporter is inhibited. The present invention further relates to a method for producing recombinant protein, and specifically, to a method for producing protein by which fucose existing within the Golgi apparatus of a host cell is decreased, a method for inhibiting the addition of fucose to protein by which fucose existing within the Golgi apparatus of a host cell is decreased upon production of recombinant protein using the host cell, a method for increasing the cytotoxic activity of an antibody by which an antibody is produced using a cell wherein fucose existing within the Golgi apparatus is decreased, and a cell having a Golgi apparatus wherein fucose existing within the Golgi apparatus is decreased.
Public/Granted literature
- US20060246456A1 Fucose transporter Public/Granted day:2006-11-02
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