Invention Grant
- Patent Title: Hepatic stellate cell specific promoter and uses thereof
- Patent Title (中): 肝星状细胞特异性启动子及其用途
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Application No.: US11916987Application Date: 2006-06-09
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Publication No.: US07863251B2Publication Date: 2011-01-04
- Inventor: Lang Zhuo , Gunter Maubach
- Applicant: Lang Zhuo , Gunter Maubach
- Applicant Address: SG Centros
- Assignee: Agency for Science, Technology and Research
- Current Assignee: Agency for Science, Technology and Research
- Current Assignee Address: SG Centros
- Agency: Klarquist Sparkman LLP
- International Application: PCT/SG2006/000149 WO 20060609
- International Announcement: WO2006/132606 WO 20061214
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/04 ; C12Q1/68
Abstract:
Methods and reagents for effecting transgene expression in Hepatic Stellate Cells (HSC) comprising a 2.2 kb fragment of the promoter region of the Glial Fibrillary Acidic Protein (GFAP) gene, said construct being up-regulated by pro-fÊbronetic cytokines such as TGF-beta 1 in a dose and time dependent manner, and uses thereof.
Public/Granted literature
- US20090202502A1 HEPATIC STELLATE CELL SPECIFIC PROMOTER AND USES THEREOF Public/Granted day:2009-08-13
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