Invention Grant
US07863280B2 Substituted 2-pyridone derivatives, method for their preparation and their use as medicament
失效
取代的2-吡啶酮衍生物,其制备方法及其用作药物
- Patent Title: Substituted 2-pyridone derivatives, method for their preparation and their use as medicament
- Patent Title (中): 取代的2-吡啶酮衍生物,其制备方法及其用作药物
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Application No.: US11733833Application Date: 2007-04-11
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Publication No.: US07863280B2Publication Date: 2011-01-04
- Inventor: Stefan Peukert , Stefan Guessregen , Armin Hofmeister , Herman Schreuder , Uwe Schwahn
- Applicant: Stefan Peukert , Stefan Guessregen , Armin Hofmeister , Herman Schreuder , Uwe Schwahn
- Applicant Address: DE Frankfurt am Main
- Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee Address: DE Frankfurt am Main
- Agent Serena Farquharson-Torres
- Priority: DE102004050196 20041015
- Main IPC: C07D401/02
- IPC: C07D401/02 ; A61K31/44

Abstract:
This invention relates to compounds of formula (I), wherein R1 and R3 independently represent fluorine, methoxy, —OCF3, C2-C3-alkenyl or C1-C4-alkyl which is optionally substituted by chlorine, methoxy or one, two or three fluorine atoms; R2 represents hydrogen, fluorine, methoxy, —OCF3, C2-C3-alkenyl or C1-C4-alkyl which is optionally substituted by chlorine, methoxy or one, two or three fluorine atoms; X represents O, S, NH or N(C1-C3-alkyl); and Ar represents an unsubstituted or at least monosubstituted aryl or heteroaryl. Said compounds are inhibitors of poly(ADP-ribose) polymerase (PARP), and may be used for the treatment of a variety of disorders.
Public/Granted literature
- US20070281948A1 SUBSTITUTED 2-PYRIDONE DERIVATIVES, METHOD FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENT Public/Granted day:2007-12-06
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