Invention Grant
- Patent Title: CXCR4 chemokine receptor binding compounds
- Patent Title (中): CXCR4趋化因子受体结合化合物
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Application No.: US11936047Application Date: 2007-11-06
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Publication No.: US07863293B2Publication Date: 2011-01-04
- Inventor: Gary J. Bridger , Ernest J. McEachern , Renato Skerlj , Dominique Schols , Ian Baird , Al Kaller , Curtis Harwig , Yongbao Zhu , Gang Chen , Krystyna Skupinska
- Applicant: Gary J. Bridger , Ernest J. McEachern , Renato Skerlj , Dominique Schols , Ian Baird , Al Kaller , Curtis Harwig , Yongbao Zhu , Gang Chen , Krystyna Skupinska
- Applicant Address: US MA Cambridge
- Assignee: Genzyme Corporation
- Current Assignee: Genzyme Corporation
- Current Assignee Address: US MA Cambridge
- Agency: Morrison & Foerster LLP
- Main IPC: C07D401/02
- IPC: C07D401/02 ; A61K31/44
Abstract:
The present invention relates to compounds that bind to chemokine receptors, and having the formula wherein each A, X, Y, R1, R2 and R3 are substituents. The present invention also relates to methods of using such compounds, such as in treating HIV infection and inflammatory conditions such as rheumatoid arthritis. Furthermore, the present invention relates to methods to elevate progenitor and stem cell counts, as well as methods to elevate white blood cell counts, using such compounds.
Public/Granted literature
- US20080255197A1 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS Public/Granted day:2008-10-16
Information query
