Invention Grant
US07863294B2 Heterocycle derivatives as histone deacetylase (HDAC) inhibitors
有权
杂环衍生物作为组蛋白脱乙酰酶（HDAC）抑制剂
- Patent Title: Heterocycle derivatives as histone deacetylase (HDAC) inhibitors
- Patent Title (中): 杂环衍生物作为组蛋白脱乙酰酶（HDAC）抑制剂
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Application No.: US11792294Application Date: 2005-12-09
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Publication No.: US07863294B2Publication Date: 2011-01-04
- Inventor: Barbara Attenni , Federica Ferrigno , Philip Jones , Raffaele Ingenito , Olaf Kinzel , Laura Llauger Bufi , Jesus Maria Ontoria , Giovanna Pescatore , Michael Rowley , Rita Scarpelli , Carsten Schultz
- Applicant: Barbara Attenni , Federica Ferrigno , Philip Jones , Raffaele Ingenito , Olaf Kinzel , Laura Llauger Bufi , Jesus Maria Ontoria , Giovanna Pescatore , Michael Rowley , Rita Scarpelli , Carsten Schultz
- Applicant Address: IT Rome
- Assignee: Instituto Di Ricerche Di Biologia Molecolare P. Angeletti SpA
- Current Assignee: Instituto Di Ricerche Di Biologia Molecolare P. Angeletti SpA
- Current Assignee Address: IT Rome
- Agent Li Su; David A. Muthard
- Priority: GB0427138.3 20041210; GB0516435.5 20050811
- International Application: PCT/GB2005/004743 WO 20051209
- International Announcement: WO2006/061638 WO 20060615
- Main IPC: A61K31/4709
- IPC: A61K31/4709 ; C07D215/227
Abstract:
The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.
Public/Granted literature
- US20090048228A1 Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors Public/Granted day:2009-02-19
Information query
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