Invention Grant
US07863299B2 Triazolyl derivatives of azabicyclo [3.1.0] hexane as dopamine D3 receptor modulators
失效
氮杂双环[3.1.0]己烷的三唑基衍生物作为多巴胺D3受体调节剂
- Patent Title: Triazolyl derivatives of azabicyclo [3.1.0] hexane as dopamine D3 receptor modulators
- Patent Title (中): 氮杂双环[3.1.0]己烷的三唑基衍生物作为多巴胺D3受体调节剂
-
Application No.: US12064118Application Date: 2006-08-18
-
Publication No.: US07863299B2Publication Date: 2011-01-04
- Inventor: Anna Maria Capelli , Elettra Fazzolari , Fabrizio Micheli , Giovanna Tedesco , Silvia Terreni
- Applicant: Anna Maria Capelli , Elettra Fazzolari , Fabrizio Micheli , Giovanna Tedesco , Silvia Terreni
- Applicant Address: GB Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Middlesex
- Agent James M. Kanagy; Edward R. Gimmi; Charles M. Kinzig
- Priority: GB0517187.1 20050822
- International Application: PCT/EP2006/008203 WO 20060818
- International Announcement: WO2007/022936 WO 20070301
- Main IPC: A61K31/428
- IPC: A61K31/428 ; A61K31/4196 ; A61K31/4439 ; C07D403/14 ; C07D417/14
![Triazolyl derivatives of azabicyclo [3.1.0] hexane as dopamine D3 receptor modulators](/abs-image/US/2011/01/04/US07863299B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to novel compounds of formula (IC) or a salt thereof: wherein: p is an integer ranging from 0 to 4; R1 is independently selected from a group consisting of: halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl or SF5; or corresponds to a group R5; m1, m2, m3, and m4 are 0; m5, m6 and m7 are each independently 0, 1 or 2 wherein the sum of m5, m6 and m7 is 1 or 2; R6 is C1-6alkyl; R7 is halogen, C1-6alkyl or haloC1-6alkyl; R2 is hydrogen or C1-4alkyl; n is 2 or 3; X is S or —CH2—; R3 is C1-4alkyl; R4 is hydrogen, or a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromatic group, or a 8- to 11-membered bicyclic group, any of which groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy and C1-4alkanoyl; R5 is isoxazolyl, —CH2—N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl or 2-pyrrolidinonyl, wherein each group is optionally substituted by one or two substituents selected from: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy and C1-4alkanoyl; with the proviso that when m5=m6=1, R7 is not chlorine; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat substance related disorders, as antipsychotic agents, premature ejaculation or cognition impairment.
Public/Granted literature
- US20080242715A1 Triazolyl Derivatives of Azabicyclo [3.1.0] Hexane as Dopamine D3 Receptor Modulators Public/Granted day:2008-10-02
Information query
IPC分类: