Invention Grant
US07863414B2 Methods of treatment and uses for CaMKII and its interaction with HDACs and calpain
有权
CaMKII的治疗和使用方法及其与HDAC和钙蛋白酶的相互作用
- Patent Title: Methods of treatment and uses for CaMKII and its interaction with HDACs and calpain
- Patent Title (中): CaMKII的治疗和使用方法及其与HDAC和钙蛋白酶的相互作用
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Application No.: US11560950Application Date: 2006-11-17
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Publication No.: US07863414B2Publication Date: 2011-01-04
- Inventor: Johannes Backs , Brooke Harrison , Khai Huynh , Keith Koch , Timothy A. McKinsey , Eric Olson , Nikos Pagratis
- Applicant: Johannes Backs , Brooke Harrison , Khai Huynh , Keith Koch , Timothy A. McKinsey , Eric Olson , Nikos Pagratis
- Applicant Address: US TX Austin US CA Foster City
- Assignee: The Board of Regents of the University of Texas Systems,Gilead Sciences, Inc.
- Current Assignee: The Board of Regents of the University of Texas Systems,Gilead Sciences, Inc.
- Current Assignee Address: US TX Austin US CA Foster City
- Agency: Fulbright & Jaworski
- Main IPC: A61K38/04
- IPC: A61K38/04
Abstract:
The present invention provides for methods of treating and cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension comprising the use of CaMKII-HDAC binding domains. The present invention discloses not only the fact that CaMKII binds to HDAC4 at a specific site, but that HDAC4 may dimerize with other HDACs. Both events can lead to export of HDACs from the nucleus to the cytoplasm, an event associated with the development of heart disease. Thus the methods of treatment and the screening methods of the present invention are novel attempts to prevent, treat or identify therapies for cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension.
Public/Granted literature
- US20070142285A1 Methods of Treatment and Uses for CaMKII and Its Interaction with HDACs and Calpain Public/Granted day:2007-06-21
Information query
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