Invention Grant
US07863424B2 Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/melanoma
有权
分离编码参与淋巴瘤/黑色素瘤发病机制的新的Fc受体型黑素瘤的五种新基因
- Patent Title: Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/melanoma
- Patent Title (中): 分离编码参与淋巴瘤/黑色素瘤发病机制的新的Fc受体型黑素瘤的五种新基因
-
Application No.: US11520183Application Date: 2006-09-12
-
Publication No.: US07863424B2Publication Date: 2011-01-04
- Inventor: Riccardo Dalla-Favera
- Applicant: Riccardo Dalla-Favera
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Cooper & Dunham LLP
- Agent John P. White
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K14/00 ; C07K16/00 ; C07K17/00 ; C07K17/14 ; A61K35/14 ; A61K38/16 ; C12P21/08
Abstract:
This invention provides an isolated nucleic acid molecule which encodes immunoglobulin receptor, Immunoglobulin superfamily Receptor Translocation Associated, IRTA, protein. Provided too, are the IRTA proteins encoded by the isolated nucleic acid molecules, IRTA1, IRTA2, IRTA3, IRTA4 or IRTA5 proteins, having the amino acid sequences set forth in any of FIG. 18A, 18B-1-18B-3, 18C-1-18C-2, 18D-1-18D-2 or 18E-1-18E-2. Oligonucleotides of the isolated nucleic acid molecules are provided. Antibodies directed to an epitope of a purified IRTA1, IRTA2, IRTA3, IRTA4 or IRTA5 proteins are also provided, as are pharmaceutical compositions comprising such antibodies or oligonucleotides. Methods for detecting a B cell malignancy in a sample from a subject; diagnosing B cell malignancy in a sample from a subject; detecting human IRTA protein in a sample; and treating a subject having a B cell cancer are also provided.
Public/Granted literature
Information query
