Invention Grant
US07863436B2 Induction of apoptosis by inhibition of sirtuin SIRT1 expression
失效
通过抑制sirtuin SIRT1表达诱导凋亡
- Patent Title: Induction of apoptosis by inhibition of sirtuin SIRT1 expression
- Patent Title (中): 通过抑制sirtuin SIRT1表达诱导凋亡
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Application No.: US10589253Application Date: 2005-02-11
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Publication No.: US07863436B2Publication Date: 2011-01-04
- Inventor: Anne Josephine Milner
- Applicant: Anne Josephine Milner
- Applicant Address: GB Yorkshire
- Assignee: The University of York
- Current Assignee: The University of York
- Current Assignee Address: GB Yorkshire
- Agency: Nixon & Vanderhye P.C.
- Priority: GB0403041.7 20040211
- International Application: PCT/GB2005/000459 WO 20050211
- International Announcement: WO2005/078091 WO 20050825
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/02 ; A61K48/00
Abstract:
The invention relates to the induction of apoptosis by inhibition of the sirtuin SIRT1 expression, in particular the induction of apoptosis in tumour cells. Materials and methods for inhibiting SIRT1 expression are provided, including RNA interference methods. In particular, the invention provides a method of treating a proliferative disease comprising administering to an individual in need thereof an effective amount of a SIRT1 inhibitor.
Public/Granted literature
- US20070197459A1 Induction of apoptosis by inhibition of sirtuin sirta expression Public/Granted day:2007-08-23
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