Invention Grant
US07863450B2 Compounds comprising an oxazoline or thiazoline moiety, processes for making them, and their uses
失效
包含恶唑啉或噻唑啉部分的化合物，其制备方法及其用途
- Patent Title: Compounds comprising an oxazoline or thiazoline moiety, processes for making them, and their uses
- Patent Title (中): 包含恶唑啉或噻唑啉部分的化合物，其制备方法及其用途
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Application No.: US11910153Application Date: 2006-03-29
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Publication No.: US07863450B2Publication Date: 2011-01-04
- Inventor: Sylvain Celanire , Patrice Talaga , Regorius Leurs , Frederic Denonne , Henkdrik Timmerman , Florence Lebon
- Applicant: Sylvain Celanire , Patrice Talaga , Regorius Leurs , Frederic Denonne , Henkdrik Timmerman , Florence Lebon
- Applicant Address: BE Brussels
- Assignee: UCB Pharma, S.A.
- Current Assignee: UCB Pharma, S.A.
- Current Assignee Address: BE Brussels
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: EP05006971 20050331
- International Application: PCT/EP2006/002860 WO 20060329
- International Announcement: WO2006/103057 WO 20061005
- Main IPC: C07D211/68
- IPC: C07D211/68 ; C07D401/00 ; A61K31/445
Abstract:
The present invention relates to compounds comprising an oxazoline or thiazoline moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3-receptor ligands, (I), wherein A1 is CH C(CH3) or N; R1 is hydrogen or halogen; R2 is (II); A2 is O or S; R3 is hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy; R4 is hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl or —O—(CH2)n-NR12aR each CH2 in —O—(CH2)n-NR12aR12b being optionally substituted by one or two C1-4 alkyl; R5 is hydrogen or —O—(CH2)m—NR13aR13b, each CH2 in —O—(CH2)m—NR13aR13b being optionally substituted by one or two C1-4 alkyl, and at least one of R4 and R5 should be a —O—(CH2)n-NR12/13aR12/13b group.
Public/Granted literature
- US20080161331A1 Compounds Comprising an Oxazoline or Thiazoline Moiety, Processes for Making Them, and Their Uses Public/Granted day:2008-07-03
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