A reference voltage regulation circuit (143) is provided in which one or more input voltage signals (Vref, Vref′) are selectively coupled to a configurable amplifier (114) which is coupled through a sample and hold circuit (120) to a voltage follower circuit (122) which is coupled in feedback to the configurable amplifier (114) for generating an adjusted output voltage at a circuit output (130), where the voltage follow circuit comprises a resistor divider circuit (126) that is controlled by a calibration signal (Cal ) generated by a counter circuit (128) selectively coupled to the output of the configurable amplifier when configured as a comparator for generating the calibration signal in response to a clock signal, where the calibration signal represents a voltage error component (Verror, Voffset) that is removed from the circuit output when the calibration signal is applied to the resistor divider circuit during normal operational.