Certain aspects of the invention for packet segmentation and offload may comprise determining whether an identified packet is a large send offload packet (LSOP). If the identified packet is a LSOP, a selection may be made between a hardware process and a firmware process for handling the LSOP. The LSOP may then be processed by the selected hardware process or firmware process. At least a portion of protocol header information for a first segment of the LSOP may be stored and subsequently utilized for at least a header portion of a second segment of the LSOP. A payload corresponding to the second segment of the LSOP may be placed at a determined offset within a transmit buffer for the second segment. A header portion of the second segment may be updated based on at least a header portion of a previous segment.