Invention Grant
- Patent Title: Heparin and heparan sulfate binding chimeric vectors
- Patent Title (中): 肝素和硫酸乙酰肝素结合嵌合载体
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Application No.: US11698505Application Date: 2007-01-26
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Publication No.: US07867484B2Publication Date: 2011-01-11
- Inventor: Richard Jude Samulski , Zhijian Wu , Aravind Asokan
- Applicant: Richard Jude Samulski , Zhijian Wu , Aravind Asokan
- Applicant Address: US NC Chapel Hill
- Assignee: University of North Carolina at Chapel Hill
- Current Assignee: University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Myers Bigel Sibley & Sajovec, P.A.
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N15/85 ; C12N15/86 ; C12N15/64
Abstract:
The present invention is based on the finding that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. In some embodiments, a substitution of a single amino acid that is unique to the AAV6 capsid (Lys-531) among other AAVs that have been characterized to date can confer one or more desirable properties to other AAVs.
Public/Granted literature
- US20070196338A1 Heparin and heparan sulfate binding chimeric vectors Public/Granted day:2007-08-23
Information query
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