Invention Grant
- Patent Title: Methods for determining conformational changes and self-assembly of proteins
- Patent Title (中): 测定蛋白质构象变化和自组装的方法
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Application No.: US11579741Application Date: 2005-02-22
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Publication No.: US07867718B2Publication Date: 2011-01-11
- Inventor: Peter Nilsson , Anna Herland , Per Hammarstrom , Peter Asberg , Olle Inganas
- Applicant: Peter Nilsson , Anna Herland , Per Hammarstrom , Peter Asberg , Olle Inganas
- Applicant Address: SE Linkoping
- Assignee: BioChromix AB
- Current Assignee: BioChromix AB
- Current Assignee Address: SE Linkoping
- Agency: Foley & Lardner LLP
- Priority: SE0401219 20040510
- International Application: PCT/SE2005/000248 WO 20050222
- International Announcement: WO2005/109005 WO 20051117
- Main IPC: G01N33/53
- IPC: G01N33/53
Abstract:
The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the protein of interest interact, and a change of a property of the polyelectrolyte in response to conformational changes of the protein is observed. The detected change is used to determine different conformations of the protein, especially the formation of amyloid fibrils.
Public/Granted literature
- US20080038751A1 Methods for Determining Conformational Changes and Self-Assembly of Proteins Public/Granted day:2008-02-14
Information query
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