Invention Grant
US07867974B2 Induction of tolerance by oral administration of factor VIII and treatment of hemophilia
有权
通过口服施用因子VIII诱导耐受性和治疗血友病
- Patent Title: Induction of tolerance by oral administration of factor VIII and treatment of hemophilia
- Patent Title (中): 通过口服施用因子VIII诱导耐受性和治疗血友病
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Application No.: US11734489Application Date: 2007-04-12
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Publication No.: US07867974B2Publication Date: 2011-01-11
- Inventor: Oral Alpan , Tirumalai Kamala , Polly Matzinger , William Hugold Velander
- Applicant: Oral Alpan , Tirumalai Kamala , Polly Matzinger , William Hugold Velander
- Applicant Address: US DC Washington US VA Blacksburg
- Assignee: The United States of America as represented by the Department of Health and Human Services,Virginia Tech Intellectual Properties, Inc.
- Current Assignee: The United States of America as represented by the Department of Health and Human Services,Virginia Tech Intellectual Properties, Inc.
- Current Assignee Address: US DC Washington US VA Blacksburg
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor other than in a liposome, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject.
Public/Granted literature
- US20070179095A1 ORAL TREATMENT OF HEMOPHILIA Public/Granted day:2007-08-02
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