Invention Grant
- Patent Title: Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
- Patent Title (中): 将伊伐布拉德及其加成盐与药学上可接受的酸合成的方法
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Application No.: US11654719Application Date: 2007-01-18
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Publication No.: US07867994B2Publication Date: 2011-01-11
- Inventor: Jean-Michel Lerestif , Jean-Pierre Lecouve , Jean-Claude Souvie , Daniel Brigot , Stephane Horvath , Marie-Noelle Auguste , Gerard Damien
- Applicant: Jean-Michel Lerestif , Jean-Pierre Lecouve , Jean-Claude Souvie , Daniel Brigot , Stephane Horvath , Marie-Noelle Auguste , Gerard Damien
- Applicant Address: FR Suresnes Cedex
- Assignee: Les Laboratoires Servier
- Current Assignee: Les Laboratoires Servier
- Current Assignee Address: FR Suresnes Cedex
- Agency: Hueschen and Sage
- Priority: FR0403830 20040413
- Main IPC: C07D223/16
- IPC: C07D223/16 ; C07D405/06 ; A61K31/55 ; A61P9/00

Abstract:
Process for the synthesis of ivabradine of formula (I): addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof. α crystalline form of ivabradine hydrochloride.Medicinal products containing α crystalline form of ivabradine hydrochloride, which are useful as bradycardics.
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