Invention Grant
- Patent Title: Compounds and compositions as protein kinase inhibitors
- Patent Title (中): 化合物和组合物作为蛋白激酶抑制剂
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Application No.: US11997113Application Date: 2006-08-09
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Publication No.: US07868018B2Publication Date: 2011-01-11
- Inventor: Yongping Xie , Guobao Zhang , Xing Wang , Nathanael S. Gray , Yi Liu
- Applicant: Yongping Xie , Guobao Zhang , Xing Wang , Nathanael S. Gray , Yi Liu
- Applicant Address: BM Hamilton
- Assignee: IRM LLC
- Current Assignee: IRM LLC
- Current Assignee Address: BM Hamilton
- Agency: Genomics Institute of the Novartis Research Foundation
- Agent Scott W. Reid
- International Application: PCT/US2006/031134 WO 20060809
- International Announcement: WO2007/021795 WO 20070222
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/4375 ; A61P35/00 ; A61P37/00 ; A61P25/00 ; A61K31/519 ; C07D413/12 ; A61K31/5355 ; A61K31/4355 ; C07D491/147
Abstract:
The invention provides compounds of Formula I: wherein R1-R6 are described in the Summary of the Invention; the pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, BMX, BTK, CHK2, b-RAF, c-RAF, CSK, c-SRC, Fes, FGFR3, Flt3, IKKα, IKKβ, JNK2α2, Lck, Met, MKK4, MKK6, MST2, NEK2, p70S6K, PDGFRβ, PKA, PKBα, PKD2, Rsk1, SAPK2α, SAPK2β, SAPK3, SGK, Tie2 and TrkB kinases.
Public/Granted literature
- US20080300246A1 Compounds and Compositions as Protein Kinase Inhibitors Public/Granted day:2008-12-04
Information query
