Invention Grant
- Patent Title: Fluorescent probe
- Patent Title (中): 荧光探针
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Application No.: US10570355Application Date: 2004-09-03
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Publication No.: US07868147B2Publication Date: 2011-01-11
- Inventor: Tetsuo Nagano , Mako Kamiya , Yasuteru Urano
- Applicant: Tetsuo Nagano , Mako Kamiya , Yasuteru Urano
- Applicant Address: JP Tokyo JP Tokyo
- Assignee: Tetsuo Nagano,Sekisui Medical Co., Ltd.
- Current Assignee: Tetsuo Nagano,Sekisui Medical Co., Ltd.
- Current Assignee Address: JP Tokyo JP Tokyo
- Agency: Greenblum & Bernstein, P.L.C.
- Priority: JP2003-314041 20030905
- International Application: PCT/JP2004/013185 WO 20040903
- International Announcement: WO2005/024049 WO 20050317
- Main IPC: C07H15/24
- IPC: C07H15/24 ; C07D311/82 ; C07D501/30 ; C07F9/12

Abstract:
A fluorescent probe which is represented by the following formula (I): (wherein, R1 represents a monovalent substituent other than hydrogen atom, carboxy group, or sulfo group; R2 represents hydrogen atom, or a monovalent substituent; R3 and R4 each independently represents hydrogen atom or a halogen atom; and R5 represents a monovalent group which is cleaved by contact with a measuring object, provided that a combination of R1 and R2 is selected so that the oxidation potential of the benzene ring to which they bind makes (1) the compound represented by the formula (I) substantially no fluorescent before the cleavage, and (2) a compound after the cleavage, which is derived from the compound represented by the formula (I), substantially highly fluorescent after the cleavage).
Public/Granted literature
- US20080014602A1 Fluorescent Probe Public/Granted day:2008-01-17
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