Invention Grant
- Patent Title: Modulation of negative immune regulators and applications for immunotherapy
- Patent Title (中): 负免疫调节剂的调节和免疫治疗的应用
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Application No.: US11335736Application Date: 2006-01-19
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Publication No.: US07868159B2Publication Date: 2011-01-11
- Inventor: Si-Yi Chen , Kevin C. Evel-Kabler , Xiaotong Song , Xue F. Huang , Andrew Sharabi
- Applicant: Si-Yi Chen , Kevin C. Evel-Kabler , Xiaotong Song , Xue F. Huang , Andrew Sharabi
- Applicant Address: US TX Houston
- Assignee: Baylor College of Medicine
- Current Assignee: Baylor College of Medicine
- Current Assignee Address: US TX Houston
- Agency: Foley & Lardner LLP
- Agent James F. Ewing
- Main IPC: C07H21/04
- IPC: C07H21/04
Abstract:
The invention includes compositions and methods for enhancing immunopotency of an immune cell by way of inhibiting a negative immune regulator in the cell. The present invention provides vaccines and therapies in which antigen presentation is enhanced through inhibition of negative immune regulators. The present invention also provides a mechanism to break self tolerance in tumor vaccination methods that rely on presentation of self tumor antigens.
Public/Granted literature
- US20060292119A1 Modulation of negative immune regulators and applications for immunotherapy Public/Granted day:2006-12-28
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